«Pendant des siècles, la Médecine s’est préoccupée de soigner. Aujourd’hui elle s'est donnée comme but de prévenir plutôt que de guérir.»
Pr Jean Dausset, Prix Nobel de Médecine, 1980
La Fondation Jean Dausset - Centre d’Etude du Polymorphisme Humain participe aux efforts nationaux et internationaux de recherche pour mieux déterminer le rôle du polymorphisme génétique chez l’Homme, tout particulièrement dans les maladies complexes, pour mieux les comprendre, les diagnostiquer et participer au développement d’une médecine personnalisée.

CEPH Families Reference Panel

The CEPH families reference panel has been established in 1984 by Professor Jean Dausset together with Daniel Cohen, Howard Cann and Mark Lathrop. Their goal was to build and lead the first international collaboration for human genome mapping. This led to the development of a collection of DNA from 40 (later 61) reference families and a database accessible to the whole scientific community including all collaborators results.

The analysis of the same set of DNAs over a large number of meiosis has allowed the building of the first genetic linkage maps of the whole human genome. More than 10 genetic maps of the human genome have been thus published. These maps allowed the localization of chromosomal regions and genes responsible for Mendelian genetic diseases.

The DNA of 30 trios (two parents and their child) of European origins were selected from the CEPH reference panel to serve as the CEU (Central EUrope) population of the HapMap project for the generation of an haplotype map of the human genome. Genotyping data for the CEU population are available at www.hapmap.org.
The same DNA sample set has been sequenced on the whole genome within the 1000 genomes project. Data are available on www.1000genomes.org.

Unlimited quantities of DNA and RNA can be produced by lymphoblastoid cell line expansion for distribution to the scientific community. The origin of families is as follow:

  • 10 French families who participated in studies of Professor Jean Dausset on HLA
  • 48 Mormon families from Utah, collected by Professor Ray White
  • 1 Pennsylvania Amish family, collected by Professor Ken Kidd
  • 2 Venezuelan families, collected by Professor Nancy Wexler

The families have in average more than 8 children and biological material from 3 generations is available for the 2/3 of them.

CEPH is distributing the DNAs since 1985. Two selections of 91 trios (including HapMap trios) and 192 unrelated Caucasian individuals are also available.

The research using biological material from the CEPH reference families has led to more than 180 publications.

CEPH Families Reference Panel Access Policy

DNAs from the CEPH families reference panel are available to the scientific community upon request via e-mail to the BRC Manager Hélène Blanché.

RNAs are extracted on request and available on a collaboration basis with the requesting laboratory.

CEPH does not have a dedicated budget for lymphoblastoid cell line expansion, nucleic acid extraction, quantifications, quality controls and distribution of DNA and RNA. Biological materials sent to collaborators are charged on a cost price recovery basis.

Requests are processed upon reception of a purchase order sent by the requesting laboratory with the following information:

  • PO date and number
  • billing address
  • Intra-European VAT number if applicable
  • CEPH IDs of requested samples (ex. : 134702...) in an Excel file
  • requested quantity in µg (5µg multiples only)
  • international courier account number (shipping fees are paid by the requesting laboratory)

This order form is to be sent via e-mail to the BRC Manager .

DNAs are usually sent the week following the order form reception. The Biobank manager will in any case inform the requesting laboratory of the shipping date.

Download the characteristics of DNAs from CEPH reference families and a ccess conditions in PDF format.

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