«Pendant des siècles, la Médecine s’est préoccupée de soigner. Aujourd’hui elle s'est donnée comme but de prévenir plutôt que de guérir.»
Pr Jean Dausset, Prix Nobel de Médecine, 1980
La Fondation Jean Dausset - Centre d’Etude du Polymorphisme Humain participe aux efforts nationaux et internationaux de recherche pour mieux déterminer le rôle du polymorphisme génétique chez l’Homme, tout particulièrement dans les maladies complexes, pour mieux les comprendre, les diagnostiquer et participer au développement d’une médecine personnalisée.

Publications du CEPH par année


Publications majeures2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007

Jouenne F, Chevret S, Bugnet E, Clappier E, Lorillon G, Meignin V, Sadoux A, Cohen S, Haziot A, How-Kit A, Kannengiesser C, Lebbé C, Gossot D, Mourah S, Tazi A. Genetic Landscape and Clinical Outcomes of Adult Langerhans Cell Histiocytosis with Lung Involvement. Eur Respir J. 2020 Feb 27;55(2). pii: 1901190. doi: 10.1183/13993003.01190-2019.

Cassius C, Amode R, Delord M, Battistella M, Poirot J, How-Kit A, Lepelletier C, Jachiet M, de Masson A, Frumholtz L, Cordoliani F, Boccara D, Lehmann-Che J, Wong J, Dubanchet S, Alberdi AJ, Merandet M, Bagot M, Bensussan A, Bouaziz JD, Le Buanec H. MDA5+ dermatomyositis is associated with stronger skin type I interferon transcriptomic signature with up-regulation of IFN-Κ transcript. J Invest Dermatol. 2020 Jan 10. pii: S0022-202X(19)33493-1. doi: 10.1016/j.jid.2019.10.020.

Anders Bergström, Shane A. McCarthy, Ruoyun Hui,Mohamed A. Almarri, Qasim Ayub, Petr Danecek, Yuan Chen, Sabine Felkel, Pille Hallast, Jack Kamm, Hélène Blanché, Jean-François Deleuze, Howard Cann, Swapan Mallick, David Reich, Manjinder S. Sandhu, Pontus Skoglund, Aylwyn Scally, Yali Xue, Richard Durbin, Chris Tyler-Smith Insights into human genetic variation and population history from 929 diverse genomes. Science 20 Mar 2020:Vol. 367, Issue 6484, eaay5012 DOI: 10.1126/science.aay5012

Zeggar HR, How-Kit A, Daunay A, Bettaieb I, Sahbatou M, Rahal K, Adouni O, Gammoudi A, Deleuze JF & Kharrat M. Tumor DNA hypomethylation of LINE-1 is associated with the tumor grade of breast cancer. Oncol Lett. 2020 Aug;20(2):1999-2006. doi: 10.3892/ol.2020.11745. Epub 2020 Jun 17.

Castro LP, Sahbatou M, Kehdy FSG, Farias AA, Yurchenko AA, de Souza TA, Rosa RCA, Mendes-Junior CT, Borda V, Munford V, Zanardo ÉA, Chehimi SN, Kulikowski LD, Aquino MM, Leal TP, Tarazona-Santos E, Chaibub SC, Gener B, Calmels N, Laugel V, Sarasin A, Menck CFM. The Iberian legacy into a young genetic xeroderma pigmentosum cluster in central Brazil. Mutat Res. 2020 Apr;852:503164. doi: 10.1016/j.mrgentox.2020.503164. Epub 2020 Feb 29.PMID: 32265042

Garali I, Sahbatou M, Daunay A, Baudrin LG, Renault V, Bouyacoub Y, Deleuze JF, How-Kit A. Improvements and inter-laboratory implementation and optimization of blood-based single-locus age prediction models using DNA methylation of the ELOVL2 promoter. Sci Rep. Accepted.

Quenez O, Cassinari K, Coutant S, Lecoquierre F, Le Guennec K, Rousseau S, Richard AC, Vasseur S, Bouvignies E, Bou J, Lienard G, Manase S, Fourneaux S, Drouot N, Nguyen-Viet V, Vezain M, Chambon P, Joly-Helas G, Le Meur N, Castelain M, Boland A, Deleuze JF; FREX Consortium, Tournier I, Charbonnier F, Kasper E, Bougeard G, Frebourg T, Saugier-Veber P, Baert-Desurmont S, Campion D, Rovelet-Lecrux A, Nicolas G. Detection of copy-number variations from NGS data using read depth information: a diagnostic performance evaluation. Eur J Hum Genet. 2020 Jun 26. doi: 10.1038/s41431-020-0672-2. Online ahead of print. PMID: 32591635

Strunz T, Lauwen S, Kiel C; International AMD Genomics Consortium (IAMDGC), Hollander AD, Weber BHF. A transcriptome-wide association study based on 27 tissues identifies 106 genes potentially relevant for disease pathology in age-related macular degeneration. Sci Rep. 2020 Jan 31;10(1):1584. doi: 10.1038/s41598-020-58510-9. PMID: 32005911

Thibord F, Munsch G, Perret C, Suchon P, Roux M, Ibrahim-Kosta M, Goumidi L, Deleuze JF, Morange PE, Trégouët DA. Bayesian network analysis of plasma microRNA sequencing data in patients with venous thrombosis. Eur Heart J Suppl. 2020 Apr;22(Suppl C):C34-C45. doi: 10.1093/eurheartj/suaa008. Epub 2020 Apr 29. PMID: 32368197

Wendeu-Foyet MG, Cénée S, Koudou Y, Trétarre B, Rébillard X, Cancel-Tassin G, Cussenot O, Boland A, Olaso R, Deleuze JF, Blanché H, Lamy PJ, Mulot C, Laurent-Puig P, Truong T, Menegaux F. Circadian genes polymorphisms, night work and prostate cancer risk: Findings from the EPICAP study. Int J Cancer. 2020 Jun 7. doi: 10.1002/ijc.33139. Online ahead of print. PMID: 32506468

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